AlphaGenome documentation#
AlphaGenome
Programmatic access to the AlphaGenome family of models and the AlphaGenome Atlas, developed by Google DeepMind. Predict the regulatory effects of DNA sequences and genetic variants, or query pre-computed variant effects across the human genome.
Our latest model. Improved cell-type specificity and generalizes to your own scRNA-seq data. Imputes unobserved modalities.
Genome-wide in silico mutagenesis across 9 billion variants, with pre-computed scores and the AlphaGenome Variant Impact (AVI) score for coding and non-coding variant prioritization. Available on a zero-code website and through the API.
The original model described in the AlphaGenome paper [Avsec et al., 2026].
The API is offered free of charge for non-commercial use. Query rates vary with demand. Atlas lookups allow higher rates than live model predictions, which suit analyses of thousands of predictions rather than millions.